Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
P-Chloroacetophenone → (E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | P-Chloroacetophenone | HCID 7467 | — |
| 반응물 | N,N,N-trimethyl-1,1-bis(1-methylethoxy)amine | HCID 87682 | — |
| 생성물 | (E)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one | HCID 5375260 | 99% |
반응 단계
A solution of 1-(4-chlorophenyl)ethane-1-one (35.0 g, 226 mmol) and N,N Dimethylformamide diisopropylacetal (35 mL) was heated to reflux for 16 hours. The reaction mixture was cooled to room temperature and treated with hexanes (50 mL). The resulting solid was collected via filtration and washed with hexanes to provide the title compound as a yellow solid (47.12 g, 99% yield): HPLC Retention Time; 6.45 min (Method B). M+1; 209.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429599B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-7b143d0fd7a04fcfb5f097754da81e17 |
| 출처 메모 | uspto-grants-2008_09 |