Isoniazid → HCID 178527959, 화합물

HRID 334510

반응식

HRID 334510 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]=[C:9]=[S:10].[C:11]([NH:19][NH2:20])(=O)[C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1>C(#N)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:11]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)=[N:19][N:20]=[C:9]1[SH:10]

참가 물질

4

반응물 2

HCID 3767IsoniazidHCID 1231711-Chloro-2-isothiocyanatobenzene

생성물 1

HCID 178527959HCID 178527959, 화합물수율 86%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-chloro-2-isothiocyanatobenzene 1 (3 g, 17.68 mmol) and isonicotinohydrazide 2 (2.43 g, 17.68 mmol) in acetonitrile was stirred at ambient temperature for 18 hours, concentrated to dryness, and 100 mL of 10% K2CO3 (aq.) was added. The resulting mixture was stirred under reflux for 6 hours. The clear solution was cooled to ambient temperature, washed with ether and acidified with 1N HCl. The solid was collected, washed with H2O and ether, and dried to afford compound 4 (4.3 g). Yield: 86%.

후처리

  1. concentrationconcentrated to dryness, and 100 mL of 10% K2CO3 (aq.)
  2. additionwas added
  3. stirringThe resulting mixture was stirred
  4. temperatureunder reflux for 6 hours
  5. temperatureThe clear solution was cooled to ambient temperature
  6. washwashed with ether
  7. customThe solid was collected
  8. washwashed with H2O and ether
  9. customdried

출처 및 근거

ORD 기록
ord-7bfce2b59fb747549e83b6259c61ed31
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883827B2

연결된 노트

불러오는 중…