Hydroxylamine → N-Hydroxy-2-methyl-benzamidine

HRID 334542

반응식

HRID 334542 반응식
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[NH2:10][OH:11].O.C(Cl)Cl.CO>CCO>[OH:11][N:10]=[C:4]([NH2:5])[C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[CH3:1]

참가 물질

6

반응물 4

HCID 787HydroxylamineHCID 962WaterHCID 107212-MethylbenzonitrileHCID 21226129Dichloromethane methanol

생성물 1

HCID 3098087N-Hydroxy-2-methyl-benzamidine수율 100%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of 2-methyl-benzonitrile (0.950 mL, 8 mmol), hydroxylamine 50% in water (1.6 mL, 24 mmol) and EtOH (8 mL) was heated at 70° C. for 48 h. TLC analysis (DCM/MeOH: 97/3 as eluent) indicates the completion of the reaction. The solvent was removed under reduced pressure to afford 1.2 g of N′-hydroxy-2-methylbenzamidine (Yield: 100%) as a white powder (M.P.=147-148.5° C.). which can be used without further purification.

후처리

  1. customthe completion of the reaction
  2. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-10ac7e740fc04206bbb1be61000b08d5
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883826B2

연결된 노트

불러오는 중…