Methylamine → 2-Chloro-N-methyl-6-nitroaniline
반응식
F[C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][NH2:13]>CCO.O>[Cl:8][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([N+:9]([O-:11])=[O:10])[C:2]=1[NH:13][CH3:12]참가 물질
5
실험 절차
2-Fluoro-3-chloronitrobenzene (3.0 g, 17 mmol) was dissolved in EtOH (6 mL) and Methylamine 40% in Water (6 mL) was added dropwise at 0° C. and mixture was warmed up to RT overnight. Mixture went to a dark orange precipitate within 10 min. The solid was isolated by filtration, rinsed with water (2*10 mL) and dried in a desiccators under vacuum to afford 3 g of 2-chloro-N-methyl-6-nitrobenzenamine (Yield: 90%) as an orange crystalline solid.
후처리
- customThe solid was isolated by filtration
- washrinsed with water (2*10 mL)
- customdried in a desiccators under vacuum
출처 및 근거
- ORD 기록
- ord-c63fabba6a4c4cf3937c0b3ca846d582
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08883826B2
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