3-Butyn-1-OL → HCID 66598264, 화합물

HRID 334761노트

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HRID 334761 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][F:9])[N:3]=1.[CH2:10]([OH:14])[CH2:11][C:12]#[CH:13]>>[F:9][CH2:8][C:4]1[N:3]=[C:2]([C:13]#[C:12][CH2:11][CH2:10][OH:14])[CH:7]=[CH:6][CH:5]=1

참가 물질

3

반응물 2

HCID 135663-Butyn-1-OLHCID 102416102-Bromo-6-(fluoromethyl)pyridine2회

생성물 1

HCID 66598264HCID 66598264, 화합물수율 80.6%

실험 절차

The title compound was prepared in accordance with the general method of Example 199(A), from 2-bromo-6-(fluoromethyl)pyridine (compound 190(E), 3.50 g, 18 mmol) and 3-butyn-1-ol (1.3 g, 18 mmol). The crude residue was purified over silicagel chromatography (prepacked 85 g silicagel column, DCM/MeOH: from 100/0 to 97/3 as eluent) to afford 2.60 g of 4-(6-(fluoromethyl)pyridin-2-yl)but-3-yn-1-ol as an orange solid (Yield: 79%).

후처리

  1. customThe crude residue was purified over silicagel chromatography (prepacked 85 g silicagel column, DCM/MeOH: from 100/0 to 97/3 as eluent)

출처 및 근거

ORD 기록
ord-2d4c39397be346b78eb65d928273ec2a
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883826B2

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