1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

참여 물질

반응 단계

To a solution of 1-hydroxy-2-naphthoic acid (10.2 g, 53.9 mmol) in 100 mL of acetic acid was added bromine (6.60 mL, 53.9 mmol) dropwise. After 72 hours, the reaction was filtered and the filter cake was washed with acetic acid (40 mL) and hexanes (150 mL) to provide 4-bromo-1-hydroxy-2-naphthoic acid that gave a proton NMR spectra consistent with theory.

출처 및 근거