1-Hydroxy-2-naphthoic acid → 4-Bromo-1-hydroxynaphthalene-2-carboxylic acid

HRID 335049

반응식

HRID 335049 반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]([OH:14])=[O:13].[Br:15]Br>C(O)(=O)C>[Br:15][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([OH:1])=[C:3]([C:12]([OH:14])=[O:13])[CH:4]=1

참가 물질

4

반응물 2

HCID 68441-Hydroxy-2-naphthoic acidHCID 24408Bromine

생성물 1

HCID 2893934-Bromo-1-hydroxynaphthalene-2-carboxylic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a solution of 1-hydroxy-2-naphthoic acid (10.2 g, 53.9 mmol) in 100 mL of acetic acid was added bromine (6.60 mL, 53.9 mmol) dropwise. After 72 hours, the reaction was filtered and the filter cake was washed with acetic acid (40 mL) and hexanes (150 mL) to provide 4-bromo-1-hydroxy-2-naphthoic acid that gave a proton NMR spectra consistent with theory.

후처리

  1. filtrationthe reaction was filtered
  2. washthe filter cake was washed with acetic acid (40 mL) and hexanes (150 mL)

출처 및 근거

ORD 기록
ord-da2eefd0dd944cde9cff264726e045a2
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883850B2

연결된 노트

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