Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[(2,6-dichlorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(2,6-dichlorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[(2,6-dichlorophenyl)methyl]-4-methoxy-2-methyl-1H-indole | HCID 10781938 | — |
| 반응물 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 생성물 | 1-[(2,6-dichlorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole | HCID 10590736 | 83.3% |
반응 단계
By the method used in Example 1, Part D, 1.08 g (3.38 mmol) of 1-[(2,6 dichlorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 13.5 mL of 1M BBr3 /CH2Cl2 to give 862 mg (83% yield) of 1-[(2,6-dichlorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole, after chromatography on silica gel (eluted with 20% EtOAc/hexane).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733923 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-996f0a7d980d4f7db95b5a7e4dbfa2a5 |
| 출처 메모 | uspto-grants-1998_03 |