Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 5-Bromo-3-(4-fluorophenoxy)picolinonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 4-Fluorophenol | HCID 9732 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 5-Bromo-3-nitropyridine-2-carbonitrile | HCID 2769698 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Bromo-3-(4-fluorophenoxy)picolinonitrile | HCID 66995028 | 78% |
반응 단계
To a solution of 4-fluorophenol (0.49 g, 4.4 mmol) in DMF (10 mL) cooled to 0° C. was added 60% sodium hydride (0.19 g, 4.8 mmol) was added and the reaction was warmed to ambient temperature. 5-Bromo-3-nitropicolinonitrile (1.0 g, 4.4 mmol, solution in 5 mL DMF) and stirred for 3 hours. Poured into water, filtered, washed with water, and dried to yield the title compound (1.0 g, 78%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08883828B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-b58cd363cc784bfa97268f8ce6c04e6e |
| 출처 메모 | uspto-grants-2014_11 |