Propanal → HCID 66995125, 화합물

HRID 335137

반응식

HRID 335137 반응식
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

참가 물질

5

반응물 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

생성물 1

HCID 66995125HCID 66995125, 화합물수율 225%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

후처리

  1. concentrationThe solution was concentrated
  2. customchromatographed

출처 및 근거

ORD 기록
ord-97d920ad523d4714be8f46d5b7eae3d2
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883828B2

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