Bromine → 5-(Benzyloxy)-3-bromopyridin-2-amine

HRID 335164노트

반응식

HRID 335164 반응식
Cl.[CH2:2]([O:9][C:10]1[CH:11]=[CH:12][C:13]([NH2:16])=[N:14][CH:15]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C([O-])(=O)C.[Na+].[Br:22]Br>C(O)(=O)C>[CH2:2]([O:9][C:10]1[CH:11]=[C:12]([Br:22])[C:13]([NH2:16])=[N:14][CH:15]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 669951705-Benzyloxy-pyridin-2-ylamine hydrochloride

생성물 1

HCID 582090735-(Benzyloxy)-3-bromopyridin-2-amine수율 17%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

5-(Benzyloxy)pyridin-2-amine hydrochloride (52.3 g, 221 mmol) and sodium acetate (45.3 g, 552 mmol) were dissolved in acetic acid (300 mL). Bromine (11.3 mL, 221 mmol) was added slowly and stirred at ambient temperature for 18 hours. After an aqueous workup, the material was purified over silica gel to give the title compound (10.5 g, 17.0% yield).

후처리

  1. customAfter an aqueous workup, the material was purified over silica gel

출처 및 근거

ORD 기록
ord-7022b441fa4d430f98dba0bc076a38b1
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883828B2

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