Iodine → 1,2-Bis(2-(trifluoromethyl)phenyl)disulfane

HRID 335212

반응식

HRID 335212 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[SH:9].II>C(#N)C>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[S:9][S:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:11])([F:10])[F:1]

참가 물질

4

반응물 2

HCID 807IodineHCID 27778892-(Trifluoromethyl)benzenethiol

생성물 1

HCID 113256811,2-Bis(2-(trifluoromethyl)phenyl)disulfane수율 88.3%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 2-(trifluoromethyl)benzenethiol (0.185 mL, 1.40 mmol) in wet acetonitrile (1:5 water/acetonitrile) was added Iodine (0.178 g, 0.702 mmol) and allowed to stir over night at room temperature. The reaction was concentrated, then diluted with EtOAc and quenched with aqueous sodium thiosulfate, extracted and dried organic with brine, Na2SO4, filtered and concentrated to afford the title compound (219 mg, 44% yield) as a colorless oil.

후처리

  1. concentrationThe reaction was concentrated
  2. additiondiluted with EtOAc
  3. customquenched with aqueous sodium thiosulfate
  4. extractionextracted and dried organic with brine, Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8686f30af43d42c38c3c3a12ee695cf5
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883828B2

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