Diisopropylamine → Methyl 4-bromo-2-methoxy-2-methylpent-4-enoate

온도

-78 °C

A 500 mL round-bottom flask was charged with diisopropylamine (12.89 mL, 92.00 mmol) and dry THF (100 mL) and cooled to −78° C. Butyllithium (2.5 M in hexanes) (36.80 mL, 92.00 mmol) was added dropwise over 20 minutes and the mixture was agitated for additional 30 minutes. Methyl 2-methoxypropanoate (10.35 g, 87.61 mmol) was added dropwise over 20 minutes and the mixture was agitated for 30 minutes. 2,3-Dibromopropene (10.70 mL, 87.61 mmol) was added dropwise over 20 minutes, the mixture was agitated for 30 minutes and then allowed to warm up to ambient temperature and agitated for additional 2 hours. The reaction was quenched with saturated ammonium chloride solution and extracted twice with ether. Extracts were washed with sodium bicarbonate solution, brine, dried and evaporated to give the title compound (22.7 g, 98.4% yield) as pale yellow oil.

1. stirringthe mixture was agitated for 30 minutes
2. stirringthe mixture was agitated for 30 minutes
3. temperatureto warm up to ambient temperature
4. stirringagitated for additional 2 hours
5. customThe reaction was quenched with saturated ammonium chloride solution
6. extractionextracted twice with ether
7. washExtracts were washed with sodium bicarbonate solution, brine
8. customdried
9. customevaporated

ORD 기록

ord-12a6afb9c809476f8edb0aaaa2d93ddc

출처 데이터셋

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08883828B2