참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Methyl 2-amino-3-thenoate | HCID 78381 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | thieno(2,3-d)pyrimidin-4(3H)-one | HCID 2808547 | 23% |
반응 단계
Methyl 2-aminothiophene-3-carboxylate (10 g, 64 mmol) was charged with formamide (50 mL). The reaction was heated at 190° C. under nitrogen for 3 hours. The solution was cooled to room temperature. The slurry was poured into 125 mL of water and extracted with chloroform:isopropyl alcohol mixture (2 times). The solution was concentrated and triturated to afford the title compound (2.25 g, 23%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08883828B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-5deb13959e074614875884ddb94d098d |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
