Formamide → thieno(2,3-d)pyrimidin-4(3H)-one

HRID 335253

반응식

HRID 335253 반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9]C)=O.[CH:11]([NH2:13])=O>O>[N:1]1[C:2]2[S:3][CH:4]=[CH:5][C:6]=2[C:7](=[O:9])[NH:13][CH:11]=1

참가 물질

4

반응물 2

HCID 713FormamideHCID 78381Methyl 2-amino-3-thenoate

생성물 1

HCID 2808547thieno(2,3-d)pyrimidin-4(3H)-one수율 23%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
190 °C

실험 절차

Methyl 2-aminothiophene-3-carboxylate (10 g, 64 mmol) was charged with formamide (50 mL). The reaction was heated at 190° C. under nitrogen for 3 hours. The solution was cooled to room temperature. The slurry was poured into 125 mL of water and extracted with chloroform:isopropyl alcohol mixture (2 times). The solution was concentrated and triturated to afford the title compound (2.25 g, 23%).

후처리

  1. temperatureThe solution was cooled to room temperature
  2. extractionextracted with chloroform
  3. concentrationThe solution was concentrated
  4. customtriturated

출처 및 근거

ORD 기록
ord-5deb13959e074614875884ddb94d098d
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883828B2

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