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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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1-Hydroxybenzotriazole → 3-Amino-4-bromo-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide

HRID 335283
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HRID 335283 반응식
CN(C)CCN=C=NCCC.[NH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Br:22])[C:16]([OH:18])=O.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=2[CH2:36][NH2:37])[CH2:26][CH2:25]1.C1C=CC2N(O)N=NC=2C=1>C(Cl)Cl>[NH2:12][C:13]1[CH:14]=[C:15]([CH:19]=[CH:20][C:21]=1[Br:22])[C:16]([NH:37][CH2:36][C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][C:30]=1[N:27]1[CH2:26][CH2:25][N:24]([CH3:23])[CH2:29][CH2:28]1)=[O:18]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 27955682-(4-Methyl-1-piperazinyl)benzenemethanamineHCID 34187523-Amino-4-Bromobenzoic AcidHCID 86695678N1,N1-dimethyl-N2-((propylimino)methylene)ethane-1,2-diamine

생성물 1

HCID 866956773-Amino-4-bromo-N-(2-(4-methylpiperazin-1-yl)benzyl)benzamide

시약·촉매·용매 1

HCID 6344
Dichloromethane
용매
2회

실험 절차

N1,N1-dimethyl-N2-((propylimino)methylene)ethane-1,2-diamine (0.70 ml, 3.99 mmol) was added to a stirred solution/suspension of 3-amino-4-bromobenzoic acid (719 mg, 3.33 mmol), (2-(4-methylpiperazin-1-yl)phenyl)methanamine (820 mg, 3.99 mmol) and HOBt (140 mg, 1.0 mmol) in dry DCM (20 ml) under argon. After 24 hrs the reaction mixture was diluted with DCM and washed several times with water. The solvent was removed in vacuo and the resulting yellow oil was triturated with DCM/diethyl to give a yellow crystalline powder;

후처리

  1. washwashed several times with water
  2. customThe solvent was removed in vacuo
  3. customthe resulting yellow oil was triturated with DCM/diethyl
  4. customto give a yellow crystalline powder

출처 및 근거

ORD 기록
ord-af0775104a0a4395ada3c99c99167468
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08883819B2

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