Dimethylformamide → Imidazo[1,2-a]pyridine-3-carbonyl Chloride

HRID 335333노트

반응식

HRID 335333 반응식
[N:1]1[CH:2]=[C:3]([C:10]([OH:12])=O)[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12.C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>C(Cl)Cl>[N:1]1[CH:2]=[C:3]([C:10]([Cl:16])=[O:12])[N:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=12

참가 물질

5

반응물 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 73142Imidazo(1,2-a)pyridine-3-carboxylic acid

생성물 1

HCID 74890117Imidazo[1,2-a]pyridine-3-carbonyl Chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A suspension of imidazo[1,2-a]pyridine-3-carboxylic acid (5.270 g, 32.5 mmol) in DCM (200 ml) was treated with oxalyl chloride (3.13 ml, 35.8 mmol) followed by the addition of DMF (0.252 ml, 3.25 mmol). The reaction mixture was stirred at RT overnight. The solvent was removed in vacuo to afford the title compound as a hydrochloride salt;

후처리

  1. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-122103a473254fb99f822a83836a206f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883819B2

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