Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Amino-9-ethylcarbazole → (2-Chloro-pyrimidin-4-yl)-(9-ethyl-9H-carbazol-3-yl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Amino-9-ethylcarbazole | HCID 8588 | — |
| 반응물 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (2-Chloro-pyrimidin-4-yl)-(9-ethyl-9H-carbazol-3-yl)-amine | HCID 89654106 | — |
반응 단계
Briefly, 2,4-dichloropyrimidine (1) was reacted with 3-amino-9-ethylcarbazole (2) by heating in iso-propanol in the presence of N,N-diisopropylethylamine. Separation of the regioisomers provided the pure 4-substituted pyrimidine derivative (3), which was reacted with 4-(3-Aminopropyl)morpholine (4) in sec-butanol under microwave heating in the presence of N,N-diisopropylethylamine to provide EHop-016 (5).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08884006B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-57420fdc378148f6b93f62605633b0d0 |
| 출처 메모 | uspto-grants-2014_11 |