2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide → 1-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine

HRID 335475

반응식

HRID 335475 반응식
[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][NH2:16])=[O:14])[CH3:2]>CO>[CH2:1]([C:3]1[CH:8]=[C:7]([CH3:9])[CH:6]=[C:5]([CH2:10][CH3:11])[C:4]=1[C:12](=[O:17])[C:13]([NH:15][N:16]=[CH:1][CH:3]([CH3:8])[CH3:4])=[O:14])[CH3:2]

참가 물질

3

반응물 1

HCID 569428732-(2,6-Diethyl-4-methylphenyl)-2-oxoacetohydrazide

생성물 1

HCID 682980701-[2-(2,6-Diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine수율 188.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 300 mL volume three-necked flask, 20.0 g of 2-(2,6-diethyl-4-methylphenyl)-2-oxoacetohydrazide ((12-1)-(11)-39), 76 ml of methanol and 12.3 g of isobutylaldehyde were added and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was concentrated under reduced pressure and then hexane was added thereto. The precipitated crystals were collected by filtration and dried under reduced pressure to give 23.2 g of 1-[2-(2,6-diethyl-4-methylphenyl)-2-oxoacetyl]-2-(2-methyl-1-propylidene)hydrazine ((40-a)-(14)-4).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. additionhexane was added
  3. filtrationThe precipitated crystals were collected by filtration
  4. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5881e2f4d94b4233b9959bc5775ceb86
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08884010B2

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