8-Aminoquinoline → HCID 178506091, 화합물

HRID 33548

반응식

HRID 33548 반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:4]=2[N:3]=1.[NH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[CH:23][CH:22]=[CH:21]2>CCO>[F:12][C:11]([F:14])([F:13])[C:9]1[CH:8]=[CH:7][C:5]2[NH:6][C:2]([NH:15][C:16]3[CH:17]=[CH:18][CH:19]=[C:20]4[C:25]=3[N:24]=[CH:23][CH:22]=[CH:21]4)=[N:3][C:4]=2[CH:10]=1

참가 물질

4

반응물 2

HCID 113598-AminoquinolineHCID 178506089HCID 178506089, 화합물

생성물 1

HCID 178506091HCID 178506091, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-chloro-5-(trifluoromethyl)-1H-benzo[d]imidazole (66 mg, 0.3 mol, prepared according to the procedure described in WO 2004/035549 A1) and 8-aminoquinoline (29 mg, 0.6 mmol, Aldrich) in EtOH (2 mL) was subjected to microwave irradiation at 170° C. with stirring for 30 min. The reaction mixture was allowed to cool to room temperature, the solvent was removed in vacuo and the residue was purified by silica gel chromatography eluting with 3% MeOH/DCM to give the title compound as an amorphous solid. MS (ESI, pos. ion) m/z: 329 (M+1).

후처리

  1. customprepared
  2. customirradiation at 170° C.
  3. customthe solvent was removed in vacuo
  4. customthe residue was purified by silica gel chromatography
  5. washeluting with 3% MeOH/DCM

출처 및 근거

ORD 기록
ord-4383ea8f71fc4c7c8aa1855bfedd5fd1
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429608B2

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