Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole → 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole | HCID 10825849 | — |
| 반응물 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 생성물 | 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole | HCID 10753503 | 84.2% |
반응 단계
By the method used in Example 1, Part D, 1.1 g (4.1 mmol) of 1-[(4-fluorophenyl)methyl]-4-methoxy-2-methyl-1H-indole was O-demethylated by treating it with 16.4 mL of 1M BBr3 /CH2Cl2 to give 881 mg (84% yield) of crude 1-[(4-fluorophenyl)methyl]-4-hydroxy-2-methyl-1H-indole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733923 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-858e366b919f470e923529fff24917ea |
| 출처 메모 | uspto-grants-1998_03 |