참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 4-(Pyrrolidin-1-yl)butan-1-amine | HCID 2762762 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Imidazole-1-carboxylic acid (4-pyrrolidin-1-yl-butyl)-amide | HCID 57552584 | — |
반응 단계
In a flask under nitrogen, 4-Pyrrolidin-1-yl-butylamine (1.3 equiv, 10.1 g) was taken up in tetrahydrofuran (105 mL, 5 volumes). The mixture was cooled to 0° C. and 1,1′-carbonyldiimidazole (1.3 equiv, 11.6 g) was added. The mixture stirred at 0° C. for 20 minutes, then warmed to 20° C. over 10 minutes and held at 20° C. for 30 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08884025B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-fd652d6a940c4feba76e780d02922705 |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
