Ethyl Acetate → 2-Dimethylamino-4-(naphth-1-yl)oxazole

HRID 33562

반응식

HRID 33562 반응식
Br[CH2:2][C:3]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][CH:6]=1)=O.[CH3:15][N:16]([CH3:20])[C:17]([NH2:19])=[O:18].C(OCC)(=O)C>CN(C)C=O>[CH3:15][N:16]([CH3:20])[C:17]1[O:18][CH:2]=[C:3]([C:5]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH:8]=[CH:7][CH:6]=2)[N:19]=1

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 11737N,N-DimethylureaHCID 38305132-Bromo-1-(1-naphthalenyl)ethanone

생성물 1

HCID 597968722-Dimethylamino-4-(naphth-1-yl)oxazole

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

1-(α-Bromoacetyl)naphthalene (5 g) and 1,1-dimethylurea (6 g) were stirred in anhydrous dimethylformamide (20 ml) at 105° C. overnight. The mixture was cooled, added to ethyl acetate, washed with sodium bicarbonate solution, water, brine, dried with sodium sulphate, filtered and evaporated in vacuo. The title compound was obtained (0.60 g; m.p. 30-32° C.) following silica gel column chromatography of the residue in dichloromethane.

후처리

  1. temperatureThe mixture was cooled
  2. washwashed with sodium bicarbonate solution, water, brine
  3. dry with materialdried with sodium sulphate
  4. filtrationfiltered
  5. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-31fee4816a474d2a8db741e1ab749da3
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429607B2

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