Diethyl Ether → HCID 50914394, 화합물

반응식

[C:1]([Li])([CH3:4])([CH3:3])[CH3:2].[CH3:6][C:7]1([CH3:12])[O:11][CH2:10][CH2:9][O:8]1.[S:13]([Cl:16])(Cl)=[O:14].CC[O:19]CC>>[CH3:6][C:7]1([CH3:12])[O:11][C@@H:10]([CH2:2][C:1]2([S:13]([Cl:16])(=[O:14])=[O:19])[CH2:4][CH2:3]2)[CH2:9][O:8]1

참가 물질

반응물 4

HCID 3283Diethyl Ether2회

HCID 24386Thionyl Chloride

HCID 762092,2-Dimethyl-1,3-dioxolane

HCID 178418306HCID 178418306, 화합물

생성물 1

HCID 50914394HCID 50914394, 화합물

반응 조건

온도: -78 °C

실험 절차

tert-Butyl lithium (2 eq) is added to a solution of (S)-4-(1-iodocyclopropyl)methyl)-2,2-dimethyl-1,3-dioxolane (1 eq) in ether at −78° C. and the mixture stirred at −78° C. for 30 mins. A solution of thionyl chloride in ether is added, the mixture warmed to room temperature and concentrated under reduced pressure. The residue is dissolved in chloroform, filtered and dried under reduced pressure.