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2,2-Dimethoxypropane → (R)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane

HRID 335639
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HRID 335639 반응식
[CH3:1][O:2][C:3]([O:6][CH3:7])([CH3:5])[CH3:4].C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1.[I:25][C:26](=[CH2:32])[CH2:27][C@@H](O)CO>ClCCl>[I:25][C:26](=[CH2:27])[CH2:32][C@@H:1]1[CH2:7][O:6][C:3]([CH3:5])([CH3:4])[O:2]1
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참가 물질

5

반응물 3

HCID 64952,2-DimethoxypropaneHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 86667890(R)-4-iodopent-4-ene-1,2-diol

생성물 1

HCID 86667889(R)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2,2-Dimethoxypropane and pyridinium p-toluenesulfonate (PPTS) are added to a solution of (R)-4-iodopent-4-ene-1,2-diol in dichloromethane and the mixture stirred at room temperature for 2 hours. Solvents are removed under reduced pressure and the crude product purified by flash chromatography using ethyl acetate/hexane (1:10) eluant.

후처리

  1. customSolvents are removed under reduced pressure
  2. customthe crude product purified by flash chromatography

출처 및 근거

ORD 기록
ord-53f03e9f827148e8aff2723741e7bf60
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08884058B2

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