Diethyl Ether → (S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride

HRID 335643노트

반응식

HRID 335643 반응식
C([Li])(C)(C)C.I[C:7](=[CH2:16])[CH2:8][C@H:9]1[CH2:13][O:12][C:11]([CH3:15])([CH3:14])[O:10]1.[S:17]([Cl:20])(Cl)=[O:18].CC[O:23]CC>>[CH3:14][C:11]1([CH3:15])[O:10][C@@H:9]([CH2:8][C:7]([S:17]([Cl:20])(=[O:18])=[O:23])=[CH2:16])[CH2:13][O:12]1

참가 물질

5

반응물 4

HCID 3283Diethyl Ether2회HCID 24386Thionyl ChlorideHCID 86667891(S)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolaneHCID 178418306HCID 178418306, 화합물

생성물 1

HCID 50914396(S)-3-(2,2-dimethyl-1,3-dioxolan-4-yl)prop-1-ene-2-sulfonyl chloride

반응 조건

온도
-78 °C

실험 절차

tert-Butyl lithium is added to a solution of (S)-4-(2-iodoallyl)-2,2-dimethyl-1,3-dioxolane in ether at −78° C. and the mixture stirred at −78° C. for 30 mins. A solution of thionyl chloride in ether is then added, the mixture warmed to room temperature and concentrated under reduced pressure. The residue is dissolved in chloroform, filtered and dried under reduced pressure.

후처리

  1. temperaturethe mixture warmed to room temperature
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue is dissolved in chloroform
  4. filtrationfiltered
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-d1e9741e79df487d872810d4131c4f87
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08884058B2

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