Sodium Carbonate → (S)-4'-fluoro-7'-(2-fluoropyridin-3-yl)-2'-(6-methylpyridazin-3-yl)-5H-spiro[oxazole-4,9'-xanthen]-2-amine

반응식

C(=O)([O-])[O-].[Na+].[Na+].[F:7][C:8]1[C:21]2[O:20][C:19]3[C:14](=[CH:15][C:16]([C:22]4[C:23]([F:28])=[N:24][CH:25]=[CH:26][CH:27]=4)=[CH:17][CH:18]=3)[C@@:13]3([CH2:32][O:31][C:30]([NH2:33])=[N:29]3)[C:12]=2[CH:11]=[C:10](B2OC(C)(C)C(C)(C)O2)[CH:9]=1.Br[C:44]1[N:45]=[N:46][C:47]([CH3:50])=[CH:48][CH:49]=1>CN(C=O)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[F:7][C:8]1[C:21]2[O:20][C:19]3[C:14](=[CH:15][C:16]([C:22]4[C:23]([F:28])=[N:24][CH:25]=[CH:26][CH:27]=4)=[CH:17][CH:18]=3)[C@@:13]3([CH2:32][O:31][C:30]([NH2:33])=[N:29]3)[C:12]=2[CH:11]=[C:10]([C:44]2[N:45]=[N:46][C:47]([CH3:50])=[CH:48][CH:49]=2)[CH:9]=1