Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-methoxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole → 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-methoxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole | HCID 10638039 | — |
| 반응물 | Boron tribromide dichloromethane | HCID 22277759 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole | HCID 10493529 | 71% |
반응 단계
By the method used in Example 1, Part D, 1.17 g (3.9 mmol) of 4-methoxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole was O-demethylated by treating it with 15.6 mL of 1M BBr3 /CH2Cl2 to give a material that was chromatographed on silica gel (eluted with 20% EtOAc/hexane then 50% EtOAc/hexane) to give 796 mg (71% yield) of 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05733923 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-ac45098226724296a2030ef33a83f824 |
| 출처 메모 | uspto-grants-1998_03 |