참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 2-Fluoro-3-methoxybenzoic acid | HCID 3390679 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6-Bromo-2-fluoro-3-methoxybenzoic acid | HCID 53438789 | 83.9% |
반응 단계
To the suspension of 2-fluoro-3-methoxybenzoic acid (20 g, 118 mmol) in Acetic Acid (100 mL) and water (100 mL) at RT, bromine (12.05 mL, 235 mmol) was added dropwise. The reaction mixture was heated for 1 h at 60° C. The reaction was then cooled to RT and white precipitate was filtered. The solid was washed with excess water and dried to give 6-bromo-2-fluoro-3-methoxybenzoic acid (24.68 g, 99 mmol) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08883782B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-5a2957c424af4dc5bd8f88bdb10436ce |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
