Diethyl Ether → N-(4,6-dimethyl-1-octyl-5-sulfamoylaminoindolin-7-yl)-2,2-dimethylpropanamide hydrochloride

HRID 33600노트

반응식

HRID 33600 반응식
C(OC([NH:8][S:9]([NH:12][C:13]1[C:14]([CH3:38])=[C:15]2[C:19](=[C:20]([NH:23][C:24](=[O:29])[C:25]([CH3:28])([CH3:27])[CH3:26])[C:21]=1[CH3:22])[N:18]([CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:17][CH2:16]2)(=[O:11])=[O:10])=O)(C)(C)C.[ClH:39].CC(O)C.C(OCC)C>C(O)=O>[ClH:39].[CH3:38][C:14]1[C:13]([NH:12][S:9](=[O:10])(=[O:11])[NH2:8])=[C:21]([CH3:22])[C:20]([NH:23][C:24](=[O:29])[C:25]([CH3:26])([CH3:27])[CH3:28])=[C:19]2[C:15]=1[CH2:16][CH2:17][N:18]2[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 21912024Isopropanol hydrochlorideHCID 23075439N-[5-(N-tert-butoxycarbonylsulfamoylamino)-4,6-dimethyl-1-octylindolin-7-yl]-2,2-dimethylpropanamide

생성물 1

HCID 23075405N-(4,6-dimethyl-1-octyl-5-sulfamoylaminoindolin-7-yl)-2,2-dimethylpropanamide hydrochloride

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

The compound (1.86 g) obtained in Example 5 was dissolved in formic acid (7.5 mL) and 8.51 M hydrogen chloride—2-propanol solution (1.98 mL) was added under ice-cooling. The mixture was stirred at the same temperature for 20 min. Diethyl ether (50 mL) was added, and the precipitated crystals were collected by filtration to give the title compound as crystals (1.34 g).

후처리

  1. temperaturecooling
  2. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-ec3ce743e04749299e8162d16b63a862
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429612B2

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