3-Pyridinylboronic acid → (S)-1-fluoro-7-(5-(prop-1-ynyl)pyridin-3-yl)-3-(pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine

HRID 336009노트

반응식

HRID 336009 반응식
Br[C:2]1[CH:3]=[C:4]2[C@@:15]3([CH2:19][O:18][C:17]([NH2:20])=[N:16]3)[C:14]3[CH:13]=[C:12](Cl)[N:11]=[C:10]([F:22])[C:9]=3[O:8][C:5]2=[CH:6][CH:7]=1.[N:23]1[CH:28]=[CH:27][CH:26]=[C:25](B(O)O)[CH:24]=1.[C:32]([C:35]1[CH:36]=[C:37](B(O)O)[CH:38]=[N:39][CH:40]=1)#[C:33][CH3:34]>>[F:22][C:10]1[C:9]2[O:8][C:5]3[C:4]([C@@:15]4([CH2:19][O:18][C:17]([NH2:20])=[N:16]4)[C:14]=2[CH:13]=[C:12]([C:25]2[CH:24]=[N:23][CH:28]=[CH:27][CH:26]=2)[N:11]=1)=[CH:3][C:2]([C:37]1[CH:38]=[N:39][CH:40]=[C:35]([C:32]#[C:33][CH3:34])[CH:36]=1)=[CH:7][CH:6]=3

참가 물질

4

반응물 3

HCID 27343783-Pyridinylboronic acidHCID 574164825-(1-Propynyl)pyridine-3-boronic Acid (contains varying amounts of Anhydride)HCID 58466258(S)-7-bromo-3-chloro-1-fluoro-5'H-spiro[chromeno[2,3-c]pyridine-5,4' oxazol]-2'-amine

생성물 1

HCID 58466193(S)-1-fluoro-7-(5-(prop-1-ynyl)pyridin-3-yl)-3-(pyridin-3-yl)-5'H-spiro[chromeno[2,3-c]pyridine-5,4'-oxazol]-2'-amine

실험 절차

The titled compound was synthesized by steps analogous to those described in method A1 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared as described in Method BB33), pyridin-3-ylboronic acid and 5-(prop-1-ynyl)pyridin-3-ylboronic acid

출처 및 근거

ORD 기록
ord-907b1d7cb5994c73b9ce94ac0d205141
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883782B2

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