Ammonia → HCID 86711276, 화합물

HRID 336136노트

반응식

HRID 336136 반응식
[NH3:1].[Si:2]([O:9][CH:10]([CH:23]=[CH2:24])[CH2:11][N:12]1[C:16]2[N:17]=[CH:18][N:19]=[C:20](Cl)[C:15]=2[C:14]([I:22])=[CH:13]1)([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3]>C1COCC1.O>[Si:2]([O:9][CH:10]([CH:23]=[CH2:24])[CH2:11][N:12]1[C:16]2[N:17]=[CH:18][N:19]=[C:20]([NH2:1])[C:15]=2[C:14]([I:22])=[CH:13]1)([C:5]([CH3:8])([CH3:7])[CH3:6])([CH3:4])[CH3:3]

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 86711275HCID 86711275, 화합물

생성물 1

HCID 86711276HCID 86711276, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
120 °C

실험 절차

25% aqueous ammonia (9 ml) was added to a solution of 7-(2-(tert-butyldimethylsilyloxy)-3-butenyl)-4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (1.12 g) obtained in Step 3 in THF (7 ml). The mixture was stirred at 120° C. for 5 hours using a microwave reactor. The reaction mixture was cooled, and then diluted with water. The resulting precipitate was collected by filtration, washed with water, and then dried to obtain the title compound as a white solid (1.06 g).

후처리

  1. temperatureThe reaction mixture was cooled
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-2aa7364982634c8dabbf510b7a17cb03
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889666B2

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