Methanol → Methyl 4-bromo-3-(trifluoromethyl)benzoate

HRID 336247노트

반응식

HRID 336247 반응식
S(Cl)(Cl)=O.[Br:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=[O:11])=[CH:8][C:7]=1[C:15]([F:18])([F:17])[F:16].[CH3:19]O>>[Br:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([O:12][CH3:19])=[O:11])=[CH:8][C:7]=1[C:15]([F:16])([F:17])[F:18]

참가 물질

4

반응물 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 247213904-Bromo-3-(trifluoromethyl)benzoic acid

생성물 1

HCID 10891333Methyl 4-bromo-3-(trifluoromethyl)benzoate

실험 절차

Thionyl chloride (16.2 mL; 223 mmol; 4 eq.) was added to a suspension of 4-bromo-3-(trifluoromethyl)benzoic acid (15 g; 55.8 mmol; 1 eq.) in MeOH (300 mL) and the reaction mixture was stirred at room temperature for 16 hours.

출처 및 근거

ORD 기록
ord-c0deb0778996457f874c849a86e345df
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889668B2

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