Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperazine → 1-(4-Methoxypyridin-2-yl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperazine | HCID 4837 | — |
| 반응물 | 2-Chloro-4-methoxypyridine | HCID 1991128 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 1-(4-Methoxypyridin-2-yl)piperazine | HCID 22648132 | 16.2% |
반응 단계
46 mg 2-chloro-4-methoxy-pyridine and 277 mg piperazine in 2 mL n-methyl-2-pyrrolidinone were stirred 45 min at 140° C. and 30 min at 200° C. under microwave conditions. The reaction was diluted with water and purified by HPLC to give 10 mg desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889677B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-63fe068426d742b984b82fa0b5cd9a08 |
| 출처 메모 | uspto-grants-2014_11 |