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Potassium Carbonate → 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone

HRID 336380
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HRID 336380 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.Br[CH2:21][C:22]([N:24]1[CH2:29][CH2:28][N:27]([C:30]2[N:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH2:26][CH2:25]1)=[O:23].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[N:10]([CH2:21][C:22]([N:24]3[CH2:25][CH2:26][N:27]([C:30]4[N:31]=[CH:32][CH:33]=[CH:34][N:35]=4)[CH2:28][CH2:29]3)=[O:23])[N:9]=2)=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 636798462-Bromo-1-(4-pyrimidin-2-ylpiperazin-1-yl)ethanoneHCID 866865153,5-bis-(4-Fluoro-phenyl)-1H-(1,2,4)triazole

생성물 1

HCID 716671292-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanone수율 69.1%

시약·촉매·용매 1

HCID 180Acetone
용매

실험 절차

100 mg 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole, 111 mg 2-bromo-1-(4-pyrimidin-2-yl-piperazin-1-yl)-ethanon and 237 mg potassiumcarbonat in 5 mL acetone was stirred 24 h at RT. The reaction was filtered and the filtrate was evaporated. The residue was crystallized with acetonitrile to yield 124 mg of the desired compound.

후처리

  1. filtrationThe reaction was filtered
  2. customthe filtrate was evaporated
  3. customThe residue was crystallized with acetonitrile

출처 및 근거

ORD 기록
ord-e32d1c6fcde94e279d860502355a0586
출처 데이터셋
uspto-grants-2014_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08889677B2

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