(R)-3-amino-4-(4-methoxy-benzylsulfanyl)-butyric acid methyl ester hydrochloride → (R)-2-[5-methanesulfonylmethyl-7-nitro-1H-indol-2-yl]-4,5-dihydro-thiazol-4-yl-acetic acid methyl ester

HRID 336467노트

반응식

HRID 336467 반응식
CO[C:3]([C:5]1[NH:6][C:7]2[C:12]([CH:13]=1)=[CH:11][C:10]([CH2:14][S:15]([CH3:18])(=[O:17])=[O:16])=[CH:9][C:8]=2[N+:19]([O-:21])=[O:20])=O.Cl.[CH3:23][O:24][C:25](=[O:40])[CH2:26][C@@H:27]([NH2:39])[CH2:28][S:29]CC1C=CC(OC)=CC=1>>[CH3:23][O:24][C:25](=[O:40])[CH2:26][C@@H:27]1[CH2:28][S:29][C:3]([C:5]2[NH:6][C:7]3[C:12]([CH:13]=2)=[CH:11][C:10]([CH2:14][S:15]([CH3:18])(=[O:16])=[O:17])=[CH:9][C:8]=3[N+:19]([O-:21])=[O:20])=[N:39]1

참가 물질

3

반응물 2

HCID 66974362(R)-3-amino-4-(4-methoxy-benzylsulfanyl)-butyric acid methyl ester hydrochlorideHCID 68485619(5-Methanesulfonylmethyl-7-nitro-1H-indol-2-yl)-carboxylic acid methylester

생성물 1

HCID 59543053(R)-2-[5-methanesulfonylmethyl-7-nitro-1H-indol-2-yl]-4,5-dihydro-thiazol-4-yl-acetic acid methyl ester

실험 절차

(5-Methanesulfonylmethyl-7-nitro-1H-indol-2-yl)-carboxylic acid methylester prepared in Step A of Preparation 44 and (R)-3-amino-4-(4-methoxy-benzylsulfanyl)-butyric acid methyl ester hydrochloride prepared in Preparation 27 were reacted according to the same procedure as Preparation 40 to give the title compound.

후처리

  1. customprepared in Preparation 27
  2. customwere reacted
  3. customaccording to the same procedure as Preparation 40

출처 및 근거

ORD 기록
ord-b3ba8313ad254f848058595abc459b71
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889691B2

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