Sodium Azide → tert-Butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate

반응식

CS(O[CH:6]1[CH2:9][C:8]2([CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]2)[CH2:7]1)(=O)=O.[N-:21]=[N+:22]=[N-:23].[Na+]>>[N:21]([CH:6]1[CH2:9][C:8]2([CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10]2)[CH2:7]1)=[N+:22]=[N-:23]

참가 물질

반응물 2

HCID 33557Sodium Azide

HCID 86660639tert-Butyl 2-[(methylsulfonyl)oxy]-6-azaspiro[3.4]octane-6-carboxylate

생성물 1

HCID 86660640tert-Butyl 2-azido-6-azaspiro[3.4]octane-6-carboxylate

실험 절차

The process is performed according to the procedure described in Example 6 (step 6.3.). Starting with 2.49 g (8.15 mmol) of tert-butyl 2-methanesulfonyloxy-6-azaspiro[3.4]octane-6-carboxylate (isomer 1), described in Example 12 (step 12.1.) and 1.07 g (16.31 mmol) of sodium azide, the product is obtained, which is used in the following step.

후처리

customthe product is obtained

출처 및 근거

ORD 기록: ord-c0bc3611bc474f4fbe85074379964c90
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08889702B2

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