Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol | HCID 64556 | — |
| 반응물 | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| 반응물 | 3,5-Dimethylpyrazole-4-boronic acid, pinacol ester | HCID 16217713 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1H-pyrazole | HCID 86681254 | — |
반응 단계
To a solution of 1-adamantanemethanol (0.090 g), 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (0.160 g) and cyanomethylenetributylphosphorane (0.215 g) were added and stirred together in toluene (2 mL) at room temperature. After stirring overnight the reaction was loaded directly onto silica gel and eluted using a gradient of 2% to 20% ethyl acetate/hexanes to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889675B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-63ff3c89dfbb4fed8261f7af31e51bea |
| 출처 메모 | uspto-grants-2014_11 |