Methanol → Methyl tricyclo[3.3.1.13,7]decane-2-carboxylate
반응식
[CH:1]12[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH:2]1[C:11]([OH:13])=[O:12])[CH2:8]2.CO.[CH3:16][Si](C=[N+]=[N-])(C)C>C(OCC)(=O)C>[CH:3]12[CH2:9][CH:7]3[CH2:6][CH:5]([CH2:10][CH:1]([CH2:8]3)[CH:2]1[C:11]([O:13][CH3:16])=[O:12])[CH2:4]2참가 물질
5
실험 절차
To a solution of adamantane-2-carboxylic acid 1 (0.486 g, 2.70 mmol) in ethyl acetate (10 mL)/methanol (5 mL) was dropwise added (trimethylsilyl)diazomethane (1.348 ml, 2.70 mmol) and the mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated and purified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes).
후처리
- concentrationThe reaction mixture was concentrated
- custompurified by flash chromotography (silica 40 g, 0%-30% ethyl acetate/hexanes)
출처 및 근거
- ORD 기록
- ord-c789df7a103c489a92c5e6de38ea8c13
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889675B2
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