Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic acid, 2-(4-formylphenoxy)- → 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic acid, 2-(4-formylphenoxy)- | HCID 89177 | — |
| 반응물 | 2-Amino-4,6-dimethoxybenzamide | HCID 20349016 | — |
| 반응물 | 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one | HCID 136038000 | — |
| 생성물 | 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid | HCID 136038018 | 21% |
반응 단계
2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid was synthesized from 2-amino-4,6-dimethoxy-benzamide and (4-formyl phenoxy)acetic acid, using the method described for 2-(4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one. 2-(4-(5,7-Dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenoxy)acetic acid (135 mg, 21%) was isolated as an off-white solid. Selected data: MS (m/z): 357.04; MP 287-290° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889698B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-03dd7199c00e40c0a0cce95de127152e |
| 출처 메모 | uspto-grants-2014_11 |