참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 4-Morpholinobenzaldehyde | HCID 291349 | — |
| 반응물 | 2-Amino-4,6-dimethoxybenzamide | HCID 20349016 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 5,7-dimethoxy-2-(4-morpholinophenyl)quinazolin-4(3H)-one | HCID 136038025 | 39% |
반응 단계
A mixture of 2-amino-4,6-dimethoxybenzamide (0.15 g, 0.765 mmol), 4-morpholin-4-yl-benzaldehyde (0.15 g, 0.765 mmol), sodium hydrogensulfite (0.136 g, 0.765 mmol) and p-toluenesulfonic acid (10 mg) in N,N-dimethyl acetamide (10 mL) was stirred at 155° C. for 14 h. The reaction mixture was cooled to room temperature and diluted with water (50 mL). The solid was collected by filtration, washed with water and MeOH to yield 5,7-dimethoxy-2-(4-morpholinophenyl)quinazolin-4(3H)-one (0.109 g, 39%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08889698B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-4494ed692c544569881c4e724697ef88 |
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| 출처 메모 | uspto-grants-2014_11 |
|---|
