참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 5-(Hydroxymethyl)furfural | HCID 237332 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 5-(Bromomethyl)-2-furaldehyde | HCID 11970491 | 87% |
반응 단계
To a solution of 3.4 g (26.7 mmol) of 5-(hydroxymethyl)furan-2-carboxaldehyde and 7.78 g (29.4 mmol) of triphenylphosphine in 300 ml of dichloromethane at −5° C. are added 5.28 g (29.4 mmol) of N-bromosuccinimide in 10 min. The mixture is stirred at −5° C. for 30 min. The mixture is then concentrated and the residue is purified by chromatography on silica (cyclohexane/AcOet: 7:3) to yield 4.38 g (87%) of 5-(bromomethyl)furan-2-carboxaldehyde in the form of a brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08889711B2 |
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| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-3384ac6afaf846c187cbe481e7a64ad1 |
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| 출처 메모 | uspto-grants-2014_11 |
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