Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → Piperidine-1-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Bromo-1-propanol | HCID 12308 | — |
| 반응물 | Water ethanol | HCID 19096565 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Piperidine-1-propanol | HCID 66032 | — |
반응 단계
A solution of potassium carbonate (24.9 g) and piperidine (130 mL) in 1:1 ethanol-water (130 mL) was treated with 3-bromopropan-1-ol (25.0 g). The resulting mixture was stirred vigorously for 20 h. Dichloromethane (200 mL) and water (50 mL) were added and the aqueous phase was extracted with dichloromethane (2×100 mL). The combined organic extracts were dried (magnesium sulfate) and evaporated in vacuo. Kugelrohr distillation of the residue (5-10 mm Hg, 120° C.) gave the title compound as a colorless oil (13.9 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429586B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-bfd5a02699f14d76aa3eefc852870588 |
| 출처 메모 | uspto-grants-2008_09 |