Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → Ammonia dichloromethane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 1-Piperidinepropanol, 2-methyl- | HCID 248806 | — |
| 반응물 | Di-tert-butyl diazene-1,2-dicarboxylate | HCID 6034084 | — |
| 반응물 | 4-Piperidin-1-ylmethyl-phenol | HCID 11636972 | — |
| 생성물 | 2-Methyl-1-[3-(4-piperidin-1-ylmethyl-phenoxy)-propyl]-piperidine | HCID 9945413 | — |
| 생성물 | Ammonia dichloromethane | HCID 22731429 | 2.5% |
반응 단계
A suspension of the product of Example 17 (176 mg), 3-(2-methyl-piperidin-1-yl)-propan-1-ol (145 mg), and polymer supported triphenylphosphine (613 mg; loading: 3 mmol/g) in DCM (5 mL) was treated with di-tert-butylazodicarboxylate (316 mg). After 2 h, the resulting mixture was filtered, and the filtrate was evaporated. Chromatography of the residue (2.5% 2 M methanolic ammonia/DCM) gave the title compound as a colorless oil (60 mg). 1H NMR (400 MHz, CDCl3): 7.20 (d, J=8.6 Hz, 2H), 6.83 (d, J=8.6 Hz, 2H), 4.01-3.92 (m, 2H), 3.40 (s, 2H), 2.90-2.81 (m, 2H), 2.56-2.47 (m, 1H), 2.40-2.25 (m, 5H), 2.21-2.14 (m, 1H), 1.97-1.88 (m, 2H), 1.70-1.51 (m, 8H), 1.45-1.25 (m, 4H), 1.07 (d, J=6.2 Hz, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429586B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-f4f114e9b4ef4aaebd94bc79e175298e |
| 출처 메모 | uspto-grants-2008_09 |