참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Heptanal | HCID 8130 | — |
| 반응물 | Benzene, 1,3-dibromo-2-methoxy- | HCID 181584 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (RS)-2-bromo-6-(1-hydroxyheptyl)anisole | HCID 59544889 | 79% |
반응 단계
To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08889722B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-53e03c4968f94623a0aa01cae23e16bf |
|---|
| 출처 메모 | uspto-grants-2014_11 |
|---|
