Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-(2-Methoxyphenyl)-3,4,5-trimethyl-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 3-Methyl-2,4-pentanedione | HCID 69949 | — |
| 반응물 | 2-Methoxyphenylhydrazine Hydrochloride | HCID 2849445 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 1-(2-Methoxyphenyl)-3,4,5-trimethyl-1H-pyrazole | HCID 55219440 | — |
반응 단계
200 mg of 2-methoxyphenyl hydrazine hydrochloride was dissolved in 4 ml of ethanol, and 134 μl of 3-methyl-2,4-pentanedione was added and heated at reflux for 3 hours. To the reaction mixture was added 50 ml of water, neutralized with a saturated aqueous solution of sodium carbonate, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 209.8 mg of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889727B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-6c70bd91c2274e9ba033fb8f22b7f8e0 |
| 출처 메모 | uspto-grants-2014_11 |