3-Fluoropentane-2,4-dione → 1-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazole

HRID 337353노트

반응식

HRID 337353 반응식
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[NH:16][NH2:17])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[F:18][CH:19]([C:23](=O)[CH3:24])[C:20](=O)[CH3:21]>C(O)C>[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[N:16]1[C:23]([CH3:24])=[C:19]([F:18])[C:20]([CH3:21])=[N:17]1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 116266523-Fluoropentane-2,4-dioneHCID 12891836(2-(Benzyloxy)phenyl)hydrazine hydrochloride

생성물 1

HCID 867032601-(2-Benzyloxyphenyl)-4-fluoro-3,5-dimethyl-1H-pyrazole수율 70.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

500 mg of 2-benzyloxyphenyl hydrazine hydrochloride and 251 mg of 3-fluoropentane-2,4-dione were added to 12 ml of ethanol, and heated at reflux for 1.5 hours. The reaction solution was concentrated under reduced pressure as it is and purified using silica gel column chromatography (hexane:ethyl acetate=6:1 to 5:1) to yield 417 mg of the title compound.

후처리

  1. temperatureheated
  2. temperatureat reflux for 1.5 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure as it
  4. custompurified

출처 및 근거

ORD 기록
ord-88a8dce911be426ba17e9c018908fdd3
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889727B2

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