3-Chloro-2,4-pentanedione → 5-bromo-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)phenol

HRID 337356

반응식

HRID 337356 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:9][NH2:10])=[C:6]([OH:8])[CH:7]=1.CC1C=CC(S([O-])(=O)=O)=CC=1.[Cl:22][CH:23]([C:27](=O)[CH3:28])[C:24](=O)[CH3:25]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([N:9]2[C:27]([CH3:28])=[C:23]([Cl:22])[C:24]([CH3:25])=[N:10]2)=[C:6]([OH:8])[CH:7]=1

참가 물질

3

반응물 2

HCID 743283-Chloro-2,4-pentanedioneHCID 1317320185-Bromo-2-hydrazinylphenol;4-methylbenzenesulfonate

생성물 1

HCID 601442025-bromo-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)phenol수율 76.9%

실험 절차

558 mg of the title compound was prepared in a manner similar to Example 54b) by using 5-bromo-2-hydrazinylphenol 4-methylbenzenesulfonate (0.9 g), which was prepared in a manner similar to Example 54a), and 3-chloropentane-2,4-dione (1.07 g).

출처 및 근거

ORD 기록
ord-ba2008632ec146f8b3539f6a2856b17f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889727B2

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