3-Hydroxy-4-nitrophenyl acetate → 4-Amino-3-hydroxyphenyl acetate

HRID 337359

반응식

HRID 337359 반응식
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[C:7]([OH:14])[CH:6]=1)(=[O:3])[CH3:2]>C(OCC)(=O)C.[Pd]>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[C:7]([OH:14])[CH:6]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 1

HCID 201396903-Hydroxy-4-nitrophenyl acetate

생성물 1

HCID 197705154-Amino-3-hydroxyphenyl acetate수율 97.5%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3-hydroxy-4-nitrophenyl acetate (3.0 g) in ethyl acetate (50 mL), 300 mg of palladium/carbon (10%) was added under nitrogen atmosphere. The resulting mixture was stirred under hydrogen atmosphere for 10 h at room temperature. The insoluble material was filtered off and the filtrate was concentrated under reduced pressure. The residue was purified by the column chromatography over silica gel using hexane/ethyl acetate(1:1) to give the title compound (2.48 g).

후처리

  1. filtrationThe insoluble material was filtered off
  2. concentrationthe filtrate was concentrated under reduced pressure
  3. customThe residue was purified by the column chromatography over silica gel

출처 및 근거

ORD 기록
ord-5b6dd432e2124df6b9238f3de8079bad
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889727B2

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