3-Methyl-2,4-pentanedione → 3-hydroxy-4-(3,4,5-trimethyl-1H-pyrazol-1-yl)phenyl acetate

반응식

[CH3:1][C:2]1[CH:7]=[CH:6]C(S(O)(=O)=O)=[CH:4][CH:3]=1.[C:12]([O:15][C:16]1[CH:21]=[CH:20][C:19]([NH:22][NH2:23])=[C:18]([OH:24])[CH:17]=1)(=[O:14])[CH3:13].C(OC1C=CC(N)=C(O)C=1)(=O)C.CC(C(=O)C)C(=O)C>>[C:12]([O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]2[C:7]([CH3:6])=[C:2]([CH3:1])[C:3]([CH3:4])=[N:23]2)=[C:18]([OH:24])[CH:17]=1)(=[O:14])[CH3:13]

참가 물질

반응물 3

HCID 699493-Methyl-2,4-pentanedione

HCID 197705154-Amino-3-hydroxyphenyl acetate

HCID 867032644-Hydrazinyl-3-hydroxyphenyl acetate 4-methylbenzenesulfonate

생성물 1

HCID 867032673-hydroxy-4-(3,4,5-trimethyl-1H-pyrazol-1-yl)phenyl acetate수율 52.2%

실험 절차

230 mg of the title compound was prepared in a manner similar to Example 54b) by using 4-hydrazinyl-3-hydroxyphenyl acetate 4-methylbenzenesulfonate (0.6 g), which was prepared from 4-amino-3-hydroxyphenyl acetate (1.0 g) in a manner similar to Example 54a), and 3-methylpentane-2,4-dione (1.0 g).

출처 및 근거

ORD 기록: ord-5ca467def39e42dd87202fabc8caaa62
출처 데이터셋: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08889727B2

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